Request for Proposals: Genome Sequencing of MGI Participants
MGI–with the generous support of Michigan Medicine’s Vice Dean for Research, Steve Kunkel, Ph.D.–is planning to perform whole-genome sequencing on DNA samples from up to 10,000 individuals from the MGI cohort.
We are asking for proposals from the UM scientific community on how to select the subset of MGI participants to be sequenced. The general properties of the MGI cohort are described at this website with more details given here and in Zawistowski et al (2023; PMCID: PMC9932985).
Sequencing depth will be 30x-40x and sequencing will be performed in the UM Department of Pathology, Division of Diagnostic Genetics and Genomics (DGG). The resulting genotypes will be CLIA compliant. Sequencing is expected to start in summer 2025 and to be completed in Q3, 2026. The generated data will be available to all researchers at the University of Michigan.
Interested investigators should submit a 1-2 page proposal that includes the following information:
Provide specific criteria to select the MGI participants to sequence. Selection might be based on a specific phenotype or phenotypes, ancestry or other demographic criteria, or on some other feature of the participants. The proposal may employ the full capacity of 10,000 samples but ideas for smaller cohorts are also welcome.
Describe how your proposal will result in high scientific impact for your own research and/or for MGI users more generally.
If the proposed sampling plan will support your own research, outline how you plan to analyze the resulting data. Provide a basic analysis plan and describe the personnel and analytic resources you have available to perform the analysis. Alternatively, if you will require help for the analysis, please describe what help you expect to need.
Submission link: https://umms.infoready4.com/#competitionDetail/1965867
Proposal Maximum Length: 2 pages. We will accept proposals until April 20th, 2025.
Please direct any question about this proposal to Anthony Antonellis antonell@umich.edu or Sebastian Zoellner szoellne@umich.edu